Athletic hand and wrist injuries may be treated by immobilizing the affected extremity in a rigid splint to protect the injury site for an extended time period. For athletes, this means a reduction in playing time, perhaps being out for an entire playing season. The use of a room temperature vulcanizing silicone rubber compound allows for a playing splint that complies with athletic regulations. Proper application of the room temperature vulcanizing silicone rubber provides an excellent, reliable protective playing splint allowing for safe, functional athletic performance for the injured player during the game. This article describes the fabrication process of a silicone rubber protective playing splint for athletic hand and wrist injuries. The effectiveness of the silicone rubber protective playing splint is illustrated via case studies.