Occupational therapists are becoming more involved in the treatment of persons with multiple personality disorder. Occupational therapy literature concerning treatment of this group of patients, however, is sparse. Clinical manifestations of multiple personality disorder include common alter personalities with distinct roles and functions, age-related behavioral patterns, and physiological differences. By recognizing and understanding these differences and characteristics and their relationship to treatment goals, occupational therapists can better use their background in life roles and occupations to increase the functional daily living skills of patients with multiple personality disorder.